Highlights

Selected publications from last 5 years


2020

Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., Li, W., Esteban, C.R., Long, X., Guo, G., Chan, P., Zhou, Q., Belmonte, J.C.I., Zhang, W., Qu, J., Liu, G.H. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. (2020) Cell. 180(5):984-1001. DOI: 10.1016/j.cell.2020.02.008

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Wang, S., Zheng, Y., Li, J., Yu, Y., Zhang, W., Song, M., Liu, Z., Min, Z., Hu, H., Jing, Y., He, X., Sun, L., Ma, L., Esteban, C.R., Chan, P., Qiao, J., Zhou, Q., Izpisua Belmonte, J.C., Qu, J., Tang, F., Liu, G.H. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. (2020) Cell. 180(3):585-600. DOI: 10.1016/j.cell.2020.01.009

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2019

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, K., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G., Izpisúa Belmonte, J.C., Ji, W., Tan, T. Dissecting primate early post-implantation development using long-term in vitro embryo culture (2019) Science. 366(6467). DOI: 10.1126/science.aaw5754

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Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H.K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J., Izpisua Belmonte, J.C. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. (2019) Cell. 179(3):687-702.e18. DOI: 10.1016/j.cell.2019.09.029

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Beyret, E., Liao, H.K., Yamamoto, M., Hernandez-Benitez, R., Fu, Y., Erikson, G., Reddy, P., Izpisua Belmonte, J.C. Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome. (2019) Nature Medicine. 25(3):419-422. DOI: 10.1038/s41591-019-0343-4

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2018

Kurita, M., Araoka, T., Hishida, T., O’Keefe, D.D., Takahashi, Y., Sakamoto, A., Sakurai, M., Suzuki, K., Wu, J., Yamamoto, M., Hernandez-Benitez, R., Ocampo, A., Reddy, P., Shokhirev, M.N., Magistretti, P., Núñez Delicado, E., Eto, H., Harii, K., Izpisua Belmonte, J.C. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. (2018) Nature. 561(7722):243-247. DOI: 10.1038/s41586-018-0477-4

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Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A.R., Kim, D., Kim, S.T., Heitner, S.B., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Amato, P., Kaul, S., Belmonte, J.C.I., Kim, J.S., Mitalipov, S. Ma et al. reply. (2018) Nature. 560(7717):E10-E23. DOI: 10.1038/s41586-018-0381-y


2017

Liao, H.K., Hatanaka, F., Araoka, T., Reddy, P., Wu, M.Z., Sui, Y., Yamauchi, T., Sakurai, M., O’Keefe, D.D., Núñez-Delicado, E., Guillen, P., Campistol, J.M., Wu, C.J., Lu, L.F., Esteban, C.R., Izpisua Belmonte, J.C. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. (2017) Cell. 171(7):1495-1507. DOI: 10.1016/j.cell.2017.10.025

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Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A.R., Kim, D., Kim, S.T., Gong, J., Gu, Y., Xu, X., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Heitner, S.B., Belmonte, J.C.I., Amato, P., Kim, J.S., Kaul, S., Mitalipov, S. Correction of a pathogenic gene mutation in human embryos. (2017) Nature. 548(7668):413-419. DOI: 10.1038/nature23305

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Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.K., Wu, M.Z., Hernández-Benítez, R., Hishida, T., Shokhirev, M.N., Esteban, C.R., Sancho-Martinez, I., Belmonte, J.C.I. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. (2017) Science. 356(6337):503-508. DOI: 10.1126/science.aag3260

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Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Sun, F., Li, X., Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte, J.C., Deng, H. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. (2017) Cell. 169(2):243-257.e25. DOI: 10.1016/j.cell.2017.02.005

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Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Bogliotti, Y.S., Cuello, C., Morales Valencia, M., Okumura, D., Luo, J., Vilariño, M., Parrilla, I., Soto, D.A., Martinez, C.A., Hishida, T., Sánchez-Bautista, S., Martinez-Martinez, M.L., Wang, H., Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Esteban, C.R., Berggren, W.T., Nuñez Delicado, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P.J., Izpisua Belmonte, J.C. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. (2017) Cell. 168(3):473-486.e15. DOI: 10.1016/j.cell.2016.12.036

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2016

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., Araoka, T., Vazquez-Ferrer, E., Donoso, D., Roman, J.L., Xu, J., Rodriguez Esteban, C., Nuñez, G., Nuñez Delicado, E., Campistol, J.M., Guillen, I., Guillen, P., Izpisua Belmonte, J.C. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) Cell. 167(7):1719-1733.e12. DOI: 10.1016/j.cell.2016.11.052

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Kang, E., Wu, J., Gutierrez, N.M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S., Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D.P., Temiakov, D., Belmonte, J.C., Amato, P., Mitalipov, S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. (2016) Nature. 540(7632):270-275. DOI: 10.1038/nature20592

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Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E.J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Fu, X., Jafari, M., Esteban, C.R., Berggren, W.T., Lajara, J., Nuñez-Delicado, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.H., Magistretti, P., Zhang, K., Callaway, E.M., Zhang, K., Belmonte, J.C. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. (2016) Nature. 540(7631):144-149. DOI: 10.1038/nature20565

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2015

Ma, H., Folmes, C.D., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N.M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P., Wolf, D.P., Huang, T., Terzic, A., Laurent, L.C., Izpisua Belmonte, J.C., Mitalipov, S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. (2015) Nature. 524(7564):234-8. DOI: 10.1038/nature14546

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Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Esteban, C.R., Tang, F., Liu, G.H., Belmonte, J.C. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. (2015) Science. 348(6239):1160-3. DOI: 10.1126/science.aaa1356

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Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R., Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaeric competency. (2015) Nature. 521(7552):316-21. DOI: 10.1038/nature14413

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Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R., Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C.R., Liu, G.H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O’Callaghan, M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T., Izpisua Belmonte, J.C. Selective elimination of mitochondrial mutations in the germline by genome editing. (2015) Cell. 161(3):459-69. DOI: 10.1016/j.cell.2015.03.051

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