Selected publications from last 5 years

2020

Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., Li, W., Esteban, C.R., Long, X., Guo, G., Chan, P., Zhou, Q., Belmonte, J.C.I., Zhang, W., Qu, J., Liu, G.H. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. (2020) Cell. 180(5):984-1001. DOI: 10.1016/j.cell.2020.02.008

Wang, S., Zheng, Y., Li, J., Yu, Y., Zhang, W., Song, M., Liu, Z., Min, Z., Hu, H., Jing, Y., He, X., Sun, L., Ma, L., Esteban, C.R., Chan, P., Qiao, J., Zhou, Q., Izpisua Belmonte, J.C., Qu, J., Tang, F., Liu, G.H. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. (2020) Cell. 180(3):585-600. DOI: 10.1016/j.cell.2020.01.009

2019

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, K., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G., Izpisúa Belmonte, J.C., Ji, W., Tan, T. Dissecting primate early post-implantation development using long-term in vitro embryo culture (2019) Science. 366(6467). DOI: 10.1126/science.aaw5754

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H.K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J., Izpisua Belmonte, J.C. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. (2019) Cell. 179(3):687-702.e18. DOI: 10.1016/j.cell.2019.09.029

Beyret, E., Liao, H.K., Yamamoto, M., Hernandez-Benitez, R., Fu, Y., Erikson, G., Reddy, P., Izpisua Belmonte, J.C. Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome. (2019) Nature Medicine. 25(3):419-422. DOI: 10.1038/s41591-019-0343-4

2018

Kurita, M., Araoka, T., Hishida, T., O’Keefe, D.D., Takahashi, Y., Sakamoto, A., Sakurai, M., Suzuki, K., Wu, J., Yamamoto, M., Hernandez-Benitez, R., Ocampo, A., Reddy, P., Shokhirev, M.N., Magistretti, P., Núñez Delicado, E., Eto, H., Harii, K., Izpisua Belmonte, J.C. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. (2018) Nature. 561(7722):243-247. DOI: 10.1038/s41586-018-0477-4

Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A.R., Kim, D., Kim, S.T., Heitner, S.B., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Amato, P., Kaul, S., Belmonte, J.C.I., Kim, J.S., Mitalipov, S. Ma et al. reply. (2018) Nature. 560(7717):E10-E23. DOI: 10.1038/s41586-018-0381-y

2017

Liao, H.K., Hatanaka, F., Araoka, T., Reddy, P., Wu, M.Z., Sui, Y., Yamauchi, T., Sakurai, M., O’Keefe, D.D., Núñez-Delicado, E., Guillen, P., Campistol, J.M., Wu, C.J., Lu, L.F., Esteban, C.R., Izpisua Belmonte, J.C. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. (2017) Cell. 171(7):1495-1507. DOI: 10.1016/j.cell.2017.10.025

Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A.R., Kim, D., Kim, S.T., Gong, J., Gu, Y., Xu, X., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Heitner, S.B., Belmonte, J.C.I., Amato, P., Kim, J.S., Kaul, S., Mitalipov, S. Correction of a pathogenic gene mutation in human embryos. (2017) Nature. 548(7668):413-419. DOI: 10.1038/nature23305

Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.K., Wu, M.Z., Hernández-Benítez, R., Hishida, T., Shokhirev, M.N., Esteban, C.R., Sancho-Martinez, I., Belmonte, J.C.I. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. (2017) Science. 356(6337):503-508. DOI: 10.1126/science.aag3260

Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Sun, F., Li, X., Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte, J.C., Deng, H. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. (2017) Cell. 169(2):243-257.e25. DOI: 10.1016/j.cell.2017.02.005

Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Bogliotti, Y.S., Cuello, C., Morales Valencia, M., Okumura, D., Luo, J., Vilariño, M., Parrilla, I., Soto, D.A., Martinez, C.A., Hishida, T., Sánchez-Bautista, S., Martinez-Martinez, M.L., Wang, H., Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Esteban, C.R., Berggren, W.T., Nuñez Delicado, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P.J., Izpisua Belmonte, J.C. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. (2017) Cell. 168(3):473-486.e15. DOI: 10.1016/j.cell.2016.12.036

2016

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., Araoka, T., Vazquez-Ferrer, E., Donoso, D., Roman, J.L., Xu, J., Rodriguez Esteban, C., Nuñez, G., Nuñez Delicado, E., Campistol, J.M., Guillen, I., Guillen, P., Izpisua Belmonte, J.C. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) Cell. 167(7):1719-1733.e12. DOI: 10.1016/j.cell.2016.11.052

Kang, E., Wu, J., Gutierrez, N.M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S., Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D.P., Temiakov, D., Belmonte, J.C., Amato, P., Mitalipov, S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. (2016) Nature. 540(7632):270-275. DOI: 10.1038/nature20592

Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E.J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Fu, X., Jafari, M., Esteban, C.R., Berggren, W.T., Lajara, J., Nuñez-Delicado, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.H., Magistretti, P., Zhang, K., Callaway, E.M., Zhang, K., Belmonte, J.C. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. (2016) Nature. 540(7631):144-149. DOI: 10.1038/nature20565

2015

Ma, H., Folmes, C.D., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N.M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P., Wolf, D.P., Huang, T., Terzic, A., Laurent, L.C., Izpisua Belmonte, J.C., Mitalipov, S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. (2015) Nature. 524(7564):234-8. DOI: 10.1038/nature14546

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Esteban, C.R., Tang, F., Liu, G.H., Belmonte, J.C. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. (2015) Science. 348(6239):1160-3. DOI: 10.1126/science.aaa1356

Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R., Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaeric competency. (2015) Nature. 521(7552):316-21. DOI: 10.1038/nature14413

Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R., Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C.R., Liu, G.H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O’Callaghan, M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T., Izpisua Belmonte, J.C. Selective elimination of mitochondrial mutations in the germline by genome editing. (2015) Cell. 161(3):459-69. DOI: 10.1016/j.cell.2015.03.051