Highlights
Selected publications from last 5 years
2020
Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., Li, W., Esteban, C.R., Long, X., Guo, G., Chan, P., Zhou, Q., Belmonte, J.C.I., Zhang, W., Qu, J., Liu, G.H. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. (2020) Cell. 180(5):984-1001. DOI: 10.1016/j.cell.2020.02.008
Wang, S., Zheng, Y., Li, J., Yu, Y., Zhang, W., Song, M., Liu, Z., Min, Z., Hu, H., Jing, Y., He, X., Sun, L., Ma, L., Esteban, C.R., Chan, P., Qiao, J., Zhou, Q., Izpisua Belmonte, J.C., Qu, J., Tang, F., Liu, G.H. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. (2020) Cell. 180(3):585-600. DOI: 10.1016/j.cell.2020.01.009
2019
Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, K., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G., Izpisúa Belmonte, J.C., Ji, W., Tan, T. Dissecting primate early post-implantation development using long-term in vitro embryo culture (2019) Science. 366(6467). DOI: 10.1126/science.aaw5754
Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H.K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J., Izpisua Belmonte, J.C. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. (2019) Cell. 179(3):687-702.e18. DOI: 10.1016/j.cell.2019.09.029
Beyret, E., Liao, H.K., Yamamoto, M., Hernandez-Benitez, R., Fu, Y., Erikson, G., Reddy, P., Izpisua Belmonte, J.C. Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome. (2019) Nature Medicine. 25(3):419-422. DOI: 10.1038/s41591-019-0343-4
2018
Kurita, M., Araoka, T., Hishida, T., O’Keefe, D.D., Takahashi, Y., Sakamoto, A., Sakurai, M., Suzuki, K., Wu, J., Yamamoto, M., Hernandez-Benitez, R., Ocampo, A., Reddy, P., Shokhirev, M.N., Magistretti, P., Núñez Delicado, E., Eto, H., Harii, K., Izpisua Belmonte, J.C. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. (2018) Nature. 561(7722):243-247. DOI: 10.1038/s41586-018-0477-4
Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A.R., Kim, D., Kim, S.T., Heitner, S.B., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Amato, P., Kaul, S., Belmonte, J.C.I., Kim, J.S., Mitalipov, S. Ma et al. reply. (2018) Nature. 560(7717):E10-E23. DOI: 10.1038/s41586-018-0381-y
2017
Liao, H.K., Hatanaka, F., Araoka, T., Reddy, P., Wu, M.Z., Sui, Y., Yamauchi, T., Sakurai, M., O’Keefe, D.D., Núñez-Delicado, E., Guillen, P., Campistol, J.M., Wu, C.J., Lu, L.F., Esteban, C.R., Izpisua Belmonte, J.C. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. (2017) Cell. 171(7):1495-1507. DOI: 10.1016/j.cell.2017.10.025
Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A.R., Kim, D., Kim, S.T., Gong, J., Gu, Y., Xu, X., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Heitner, S.B., Belmonte, J.C.I., Amato, P., Kim, J.S., Kaul, S., Mitalipov, S. Correction of a pathogenic gene mutation in human embryos. (2017) Nature. 548(7668):413-419. DOI: 10.1038/nature23305
Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.K., Wu, M.Z., Hernández-Benítez, R., Hishida, T., Shokhirev, M.N., Esteban, C.R., Sancho-Martinez, I., Belmonte, J.C.I. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. (2017) Science. 356(6337):503-508. DOI: 10.1126/science.aag3260
Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Sun, F., Li, X., Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte, J.C., Deng, H. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. (2017) Cell. 169(2):243-257.e25. DOI: 10.1016/j.cell.2017.02.005
Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Bogliotti, Y.S., Cuello, C., Morales Valencia, M., Okumura, D., Luo, J., Vilariño, M., Parrilla, I., Soto, D.A., Martinez, C.A., Hishida, T., Sánchez-Bautista, S., Martinez-Martinez, M.L., Wang, H., Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Esteban, C.R., Berggren, W.T., Nuñez Delicado, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P.J., Izpisua Belmonte, J.C. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. (2017) Cell. 168(3):473-486.e15. DOI: 10.1016/j.cell.2016.12.036
2016
Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., Araoka, T., Vazquez-Ferrer, E., Donoso, D., Roman, J.L., Xu, J., Rodriguez Esteban, C., Nuñez, G., Nuñez Delicado, E., Campistol, J.M., Guillen, I., Guillen, P., Izpisua Belmonte, J.C. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) Cell. 167(7):1719-1733.e12. DOI: 10.1016/j.cell.2016.11.052
Kang, E., Wu, J., Gutierrez, N.M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S., Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D.P., Temiakov, D., Belmonte, J.C., Amato, P., Mitalipov, S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. (2016) Nature. 540(7632):270-275. DOI: 10.1038/nature20592
Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E.J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Fu, X., Jafari, M., Esteban, C.R., Berggren, W.T., Lajara, J., Nuñez-Delicado, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.H., Magistretti, P., Zhang, K., Callaway, E.M., Zhang, K., Belmonte, J.C. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. (2016) Nature. 540(7631):144-149. DOI: 10.1038/nature20565
2015
Ma, H., Folmes, C.D., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N.M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P., Wolf, D.P., Huang, T., Terzic, A., Laurent, L.C., Izpisua Belmonte, J.C., Mitalipov, S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. (2015) Nature. 524(7564):234-8. DOI: 10.1038/nature14546
Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Esteban, C.R., Tang, F., Liu, G.H., Belmonte, J.C. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. (2015) Science. 348(6239):1160-3. DOI: 10.1126/science.aaa1356
Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R., Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaeric competency. (2015) Nature. 521(7552):316-21. DOI: 10.1038/nature14413
Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R., Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C.R., Liu, G.H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O’Callaghan, M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T., Izpisua Belmonte, J.C. Selective elimination of mitochondrial mutations in the germline by genome editing. (2015) Cell. 161(3):459-69. DOI: 10.1016/j.cell.2015.03.051